1 00:00:00,166 --> 00:00:01,900 Terminally ill 2 00:00:02,133 --> 00:00:03,766 Psycho-neuroimmunology has the answer. 3 00:00:04,366 --> 00:00:06,900 According to statistics from the global medical literature 4 00:00:06,900 --> 00:00:09,433 Per 100,000 cancer patients 5 00:00:09,466 --> 00:00:10,800 About one person 6 00:00:10,800 --> 00:00:13,933 You experience a phenomenon called spontaneous remission. 7 00:00:13,966 --> 00:00:14,933 That is to say 8 00:00:14,933 --> 00:00:16,100 Their cancer 9 00:00:16,133 --> 00:00:18,733 Without adequate treatment 10 00:00:18,766 --> 00:00:20,733 Partial or even complete disappearance 11 00:00:21,100 --> 00:00:22,266 You might think 12 00:00:22,266 --> 00:00:23,566 One in 100,000 13 00:00:23,566 --> 00:00:24,800 The probability is too low 14 00:00:24,800 --> 00:00:26,600 What does it have to do with me? 15 00:00:26,766 --> 00:00:28,466 But think about it another way. 16 00:00:28,466 --> 00:00:31,800 There are almost 20 million new cases of cancer every year. 17 00:00:31,833 --> 00:00:34,600 One in 100,000 means maybe 200 a year. 18 00:00:34,633 --> 00:00:38,100 There are about 10 documented cases of spontaneous remission 19 00:00:38,133 --> 00:00:39,300 Not reported 20 00:00:39,300 --> 00:00:40,400 Maybe more. 21 00:00:40,733 --> 00:00:41,766 So here's the problem. 22 00:00:41,766 --> 00:00:44,633 Of the 200 or so documented cases 23 00:00:44,633 --> 00:00:46,033 So what happened? 24 00:00:46,033 --> 00:00:47,266 What did they do? 25 00:00:47,266 --> 00:00:48,400 Or do nothing 26 00:00:48,400 --> 00:00:50,333 Let the cancer go away on its own 27 00:00:50,633 --> 00:00:51,700 But here's the thing. 28 00:00:51,700 --> 00:00:53,833 Can this process be understood? 29 00:00:53,866 --> 00:00:55,233 Can it be replicated? 30 00:00:55,533 --> 00:00:56,200 Hello 31 00:00:56,233 --> 00:00:57,233 Hello. 32 00:00:57,500 --> 00:00:58,500 I am Wang Lijie 33 00:00:58,833 --> 00:01:01,033 I'm going to take apart the topic today. 34 00:01:01,033 --> 00:01:03,700 It's not about spiritual healing. 35 00:01:03,700 --> 00:01:06,433 It is not a positive energy that inspires the universe 36 00:01:06,466 --> 00:01:08,100 But a serious 37 00:01:08,133 --> 00:01:11,600 Scientific questions supported by a wealth of medical literature 38 00:01:12,266 --> 00:01:13,466 Here's what I'm going to do. 39 00:01:13,466 --> 00:01:16,466 Using the cognitive framework that our channel has established 40 00:01:16,500 --> 00:01:20,033 Especially predictive coding and positive mind-body feedback closed loop 41 00:01:20,033 --> 00:01:24,433 To explain the possible neuroimmunological mechanisms behind spontaneous remission 42 00:01:24,633 --> 00:01:26,133 Let's look at the data first 43 00:01:26,166 --> 00:01:27,300 1993 44 00:01:27,600 --> 00:01:30,833 A research organization called IONS released a book 45 00:01:30,833 --> 00:01:33,633 It's called Spontaneous Remission: An Annotated Bibliography. 46 00:01:34,066 --> 00:01:36,233 It was founded by Apollo XIV. 47 00:01:36,233 --> 00:01:38,800 Moon landing astronaut Edgar Mitchell 48 00:01:38,833 --> 00:01:42,366 After his return from the moon, he underwent a profound shift in consciousness 49 00:01:42,366 --> 00:01:45,166 I spent the rest of my life studying the nature of consciousness 50 00:01:45,166 --> 00:01:48,733 I told his story earlier in the Space Overview Effect issue 51 00:01:48,900 --> 00:01:52,900 This book does something really important that no one had systematically done before. 52 00:01:52,900 --> 00:01:55,500 It publishes more than 800 medical journals worldwide 53 00:01:55,533 --> 00:01:58,800 Cases of spontaneous remission reported in 20 languages 54 00:01:58,833 --> 00:02:01,033 All collected and organized together 55 00:02:01,033 --> 00:02:04,066 It ended up with over 3,500 cases. 56 00:02:04,066 --> 00:02:07,466 This is the largest database of spontaneous responses in the world at that time 57 00:02:07,666 --> 00:02:08,900 2025 58 00:02:08,900 --> 00:02:12,700 This database has been updated to an online searchable version 59 00:02:12,733 --> 00:02:16,233 The extension includes new cases up to 2025 60 00:02:16,700 --> 00:02:17,500 Attention 61 00:02:17,533 --> 00:02:20,333 This is not a collection of testimonials from a spiritual community 62 00:02:20,600 --> 00:02:24,633 Every one of these cases is from a paper in a legitimate medical journal. 63 00:02:24,633 --> 00:02:25,766 There is a diagnostic record 64 00:02:25,800 --> 00:02:27,633 There is radiographic evidence 65 00:02:27,633 --> 00:02:28,833 There is a pathology report 66 00:02:28,866 --> 00:02:32,466 The medical definition of spontaneous remission is very strict 67 00:02:32,466 --> 00:02:33,666 Without treatment 68 00:02:33,666 --> 00:02:38,433 Or the treatment received is considered insufficient to produce the effect 69 00:02:38,466 --> 00:02:41,600 Partial or complete disappearance of a disease or tumor 70 00:02:42,033 --> 00:02:43,133 In other words 71 00:02:43,133 --> 00:02:44,800 According to existing medical knowledge 72 00:02:44,800 --> 00:02:46,400 These people shouldn't be fine 73 00:02:46,433 --> 00:02:47,800 But they are fine 74 00:02:48,266 --> 00:02:50,233 Now the second key source of data 75 00:02:50,300 --> 00:02:52,133 University of California, Berkeley 76 00:02:52,133 --> 00:02:54,366 There's a researcher named Kelly Turner 77 00:02:54,700 --> 00:02:58,233 She got her Ph.D. on spontaneous remission. 78 00:02:58,233 --> 00:02:59,733 She went to 10 different countries. 79 00:02:59,766 --> 00:03:01,933 Fifty alternative therapies were interviewed face-to-face 80 00:03:01,933 --> 00:03:05,100 The therapist and 20 survivors of spontaneous remission 81 00:03:05,133 --> 00:03:07,666 And she expanded on that. 82 00:03:07,666 --> 00:03:11,033 Ultimately analyzed over 1,500 cases of spontaneous remission 83 00:03:11,266 --> 00:03:14,000 Turner discovered a very interesting phenomenon 84 00:03:14,033 --> 00:03:15,166 In these cases 85 00:03:15,166 --> 00:03:18,666 And she identified 75 possible correlations. 86 00:03:18,666 --> 00:03:20,533 But there are nine factors. 87 00:03:20,533 --> 00:03:23,533 Repeated in almost all cases 88 00:03:23,566 --> 00:03:27,066 These nine factors were later written into a New York Times bestseller by her 89 00:03:27,066 --> 00:03:28,400 90 00:03:28,433 --> 00:03:30,533 Chinese reference translation name < Complete Relief > 91 00:03:30,700 --> 00:03:32,600 I will read these nine factors to you 92 00:03:32,633 --> 00:03:33,533 You pay attention 93 00:03:33,533 --> 00:03:35,533 Don't jump to conclusions after listening 94 00:03:35,566 --> 00:03:37,666 See what your gut feeling will tell you 95 00:03:38,000 --> 00:03:38,633 first 96 00:03:38,633 --> 00:03:40,233 Revolutionize your diet 97 00:03:40,233 --> 00:03:41,000 second 98 00:03:41,033 --> 00:03:42,933 Take control of your own health decisions 99 00:03:42,933 --> 00:03:43,733 third 100 00:03:43,733 --> 00:03:44,966 Follow your instincts 101 00:03:45,000 --> 00:03:45,900 fourth 102 00:03:45,900 --> 00:03:48,133 Use of herbal remedies and nutritional supplements 103 00:03:48,166 --> 00:03:48,900 fifth 104 00:03:48,900 --> 00:03:50,400 Release suppressed emotions 105 00:03:50,400 --> 00:03:51,133 sixth 106 00:03:51,133 --> 00:03:53,033 Increase positive emotions 107 00:03:53,066 --> 00:03:53,866 seventh 108 00:03:53,866 --> 00:03:55,500 Embrace social support 109 00:03:55,533 --> 00:03:56,300 eighth 110 00:03:56,300 --> 00:03:57,800 Deepening spiritual connections 111 00:03:58,000 --> 00:03:58,766 ninth 112 00:03:58,766 --> 00:04:01,000 Have a strong reason to live 113 00:04:01,566 --> 00:04:02,800 Did you find it? 114 00:04:03,000 --> 00:04:04,233 Of the nine factors 115 00:04:04,233 --> 00:04:05,966 In addition to diet and supplements 116 00:04:06,000 --> 00:04:09,400 The remaining seven are all psychological and behavioral factors 117 00:04:09,866 --> 00:04:10,866 It's not a new drug. 118 00:04:10,866 --> 00:04:12,500 It's not a new surgery. 119 00:04:12,533 --> 00:04:14,733 Not some kind of black tech treatment 120 00:04:15,100 --> 00:04:16,500 It's a psychological shift. 121 00:04:16,900 --> 00:04:19,800 This means that in these cases of spontaneous remission 122 00:04:19,800 --> 00:04:22,566 Some deep psychological and behavioral changes 123 00:04:22,566 --> 00:04:24,300 And the regression of the cancer 124 00:04:24,333 --> 00:04:26,166 There is a high degree of correlation 125 00:04:26,300 --> 00:04:27,000 Attention please. 126 00:04:27,000 --> 00:04:28,466 I'm talking about relevance. 127 00:04:28,500 --> 00:04:29,800 It's not causality. 128 00:04:29,800 --> 00:04:34,000 Turner himself is very careful to call these nine factors hypotheses 129 00:04:34,200 --> 00:04:36,433 Call for more research to verify 130 00:04:36,466 --> 00:04:38,333 This distinction is very important 131 00:04:38,933 --> 00:04:42,433 But the correlation itself is shocking enough 132 00:04:42,433 --> 00:04:44,733 Because it points to a core issue 133 00:04:44,766 --> 00:04:47,966 Can mental states affect the course of cancer? 134 00:04:48,133 --> 00:04:49,100 If you can 135 00:04:49,100 --> 00:04:50,733 Through what mechanism? 136 00:04:50,833 --> 00:04:53,900 Let me put this question on the table in neuroscience. 137 00:04:54,266 --> 00:04:55,300 Over the past 40 years 138 00:04:55,300 --> 00:04:57,766 There's a discipline that's been working on this question. 139 00:04:57,766 --> 00:04:59,833 It's called psychoneuroimmunology. 140 00:05:00,100 --> 00:05:02,466 The name itself says it all 141 00:05:02,866 --> 00:05:03,666 psychology 142 00:05:03,666 --> 00:05:04,500 nerve 143 00:05:04,500 --> 00:05:05,300 immune 144 00:05:05,333 --> 00:05:07,666 How are the three systems interconnected? 145 00:05:08,366 --> 00:05:09,966 Let's first understand a basic fact 146 00:05:10,333 --> 00:05:14,300 There are cells in your immune system called natural killer cells. 147 00:05:14,333 --> 00:05:16,233 Abbreviated as NK cells, NK 148 00:05:16,233 --> 00:05:18,366 Cells are your body's patrols 149 00:05:18,400 --> 00:05:20,933 They're constantly running through your bloodstream. 150 00:05:20,933 --> 00:05:23,600 Specializes in identifying and killing two things 151 00:05:23,633 --> 00:05:25,433 Virus-infected cells 152 00:05:25,433 --> 00:05:26,800 And cancerous cells 153 00:05:26,800 --> 00:05:27,200 Right 154 00:05:27,233 --> 00:05:28,933 You heard right. 155 00:05:28,933 --> 00:05:32,300 Your body produces a small number of cancerous cells every day 156 00:05:32,300 --> 00:05:33,866 But you don't have cancer. 157 00:05:33,900 --> 00:05:37,200 Precisely because NK cells patrol day and night 158 00:05:37,233 --> 00:05:39,233 Find one kill one 159 00:05:39,233 --> 00:05:41,033 This process is called immune surveillance. 160 00:05:42,333 --> 00:05:45,600 Immune surveillance is one of your body's most important defenses 161 00:05:45,633 --> 00:05:47,433 It's nothing new. 162 00:05:47,433 --> 00:05:51,766 Immune surveillance theory was first proposed in the 1950s 163 00:05:51,766 --> 00:05:53,600 And there was a lot of evidence. 164 00:05:53,600 --> 00:05:55,500 People with suppressed immune function 165 00:05:55,500 --> 00:05:58,800 For example, patients taking immunosuppressants after an organ transplant 166 00:05:58,800 --> 00:06:00,766 Significant increase in cancer incidence 167 00:06:00,800 --> 00:06:04,500 This directly demonstrates the critical role of the immune system in suppressing tumors 168 00:06:05,366 --> 00:06:06,033 OK 169 00:06:06,066 --> 00:06:09,766 Remember these two concepts of NK cells and immune surveillance 170 00:06:09,766 --> 00:06:12,200 Because everything that follows is about them 171 00:06:12,633 --> 00:06:13,966 Now here's the problem. 172 00:06:14,000 --> 00:06:17,000 What suppresses the activity of NK cells? 173 00:06:17,133 --> 00:06:18,133 Here's the answer. 174 00:06:18,133 --> 00:06:19,066 chronic stress 175 00:06:19,400 --> 00:06:20,900 Here's how it works. 176 00:06:20,900 --> 00:06:23,533 When you are under chronic stress 177 00:06:23,566 --> 00:06:26,300 Your hypothalamic-pituitary-adrenal axis 178 00:06:26,300 --> 00:06:28,200 HPA axis for short 179 00:06:28,233 --> 00:06:29,633 Will be continuously activated, HPA 180 00:06:30,233 --> 00:06:32,733 What is the result of HPA axis activation? 181 00:06:32,733 --> 00:06:36,700 Sustained release of high levels of cortisol and catecholamines 182 00:06:36,733 --> 00:06:38,166 Also known as stress hormones 183 00:06:38,966 --> 00:06:41,233 If you have seen my previous issue of < Mind and Body Restart > 184 00:06:41,233 --> 00:06:43,833 You should already be familiar with the HPA axis 185 00:06:43,833 --> 00:06:47,900 I was talking about the feedback loop between mood and inflammation. 186 00:06:47,933 --> 00:06:49,833 Negative emotions trigger inflammation 187 00:06:49,833 --> 00:06:51,700 Inflammation damages the nervous system 188 00:06:51,733 --> 00:06:54,866 A damaged nervous system generates more negative emotions 189 00:06:54,866 --> 00:06:57,400 More negative emotions trigger more severe inflammation 190 00:06:57,400 --> 00:06:58,300 Avalanche 191 00:06:58,300 --> 00:06:59,200 nuclear fission 192 00:06:59,200 --> 00:07:01,266 Output Wrap Amplification Large Deviation 193 00:07:01,266 --> 00:07:02,366 System out of control 194 00:07:03,033 --> 00:07:04,366 Today you will see 195 00:07:04,366 --> 00:07:07,366 The cancer story follows the same path as that closed loop. 196 00:07:08,500 --> 00:07:10,166 Numerous studies have confirmed 197 00:07:10,366 --> 00:07:14,766 Persistently high cortisol levels directly inhibit the activity of NK cells 198 00:07:15,200 --> 00:07:16,300 Published in Nature 199 00:07:16,300 --> 00:07:18,400 200 00:07:18,400 --> 00:07:20,200 The review clearly states that 201 00:07:20,200 --> 00:07:21,566 glucocorticoid 202 00:07:21,866 --> 00:07:24,100 That's the hormone cortisol. 203 00:07:24,133 --> 00:07:27,233 It can directly inactivate the killing function of NK cells 204 00:07:27,233 --> 00:07:30,966 And this inactivation does not require a reduction in the number of NK cells 205 00:07:31,000 --> 00:07:33,133 Just turn off its battle mode. 206 00:07:34,066 --> 00:07:35,866 Think about what that means. 207 00:07:35,866 --> 00:07:37,866 Your patrol is still on patrol 208 00:07:37,900 --> 00:07:39,766 But their weapons were taken away 209 00:07:39,866 --> 00:07:41,266 They pass by cancerous cells. 210 00:07:41,266 --> 00:07:42,800 No bullets in the gun 211 00:07:43,133 --> 00:07:44,333 And not only that. 212 00:07:44,533 --> 00:07:47,433 Chronic stress can also interfere with DNA repair mechanisms 213 00:07:47,666 --> 00:07:49,066 Promotes chronic inflammation 214 00:07:49,266 --> 00:07:52,166 Altering the cytokine balance in the tumor microenvironment 215 00:07:52,566 --> 00:07:57,633 Switch the immune environment from tumor-attacking mode to tumor-tolerant mode 216 00:07:58,266 --> 00:07:59,500 This is not hypothetical. 217 00:07:59,500 --> 00:08:04,433 This is a mechanism that has been validated in both animal models and human clinical studies 218 00:08:04,466 --> 00:08:08,100 A study of patients with advanced breast cancer found that 219 00:08:08,100 --> 00:08:11,133 Those with higher average daytime cortisol concentrations 220 00:08:11,133 --> 00:08:13,500 Patients with more severe depressive symptoms 221 00:08:13,533 --> 00:08:15,966 Cellular immunity is significantly suppressed 222 00:08:16,700 --> 00:08:19,133 Another study of ovarian cancer patients found that 223 00:08:19,533 --> 00:08:22,033 Patients with high levels of social support 224 00:08:22,033 --> 00:08:27,266 NK cell activity was higher in the tumor microenvironment and in peripheral blood 225 00:08:27,300 --> 00:08:29,133 And socially isolated patients 226 00:08:29,133 --> 00:08:32,233 Tumors had higher levels of norepinephrine. 227 00:08:32,233 --> 00:08:35,266 Means that the stress signal penetrates directly into the tumor 228 00:08:35,833 --> 00:08:37,433 And I'm going to draw the causal chain. 229 00:08:37,800 --> 00:08:39,166 Chronic psychological stress 230 00:08:39,200 --> 00:08:41,900 Activate the HPA axis and the sympathetic nervous system 231 00:08:41,900 --> 00:08:44,500 Release cortisol and catecholamines 232 00:08:44,533 --> 00:08:47,766 Suppression of NK cell activity and overall cellular immunity 233 00:08:47,800 --> 00:08:49,733 Decreased immune surveillance 234 00:08:49,733 --> 00:08:51,166 Cancer cells gain escape space 235 00:08:52,000 --> 00:08:54,600 This link is supported by solid scientific evidence. 236 00:08:54,600 --> 00:08:55,600 This is not speculation 237 00:08:56,300 --> 00:08:56,966 OK 238 00:08:56,966 --> 00:08:59,466 Now let me reverse the logic. 239 00:09:00,066 --> 00:09:03,600 If chronic stress suppresses the immune system through this pathway 240 00:09:03,600 --> 00:09:04,100 So... 241 00:09:04,100 --> 00:09:07,133 When a person undergoes a deep psychological transformation 242 00:09:07,133 --> 00:09:09,633 Free yourself from chronic stress 243 00:09:09,633 --> 00:09:12,833 Can this path run in the opposite direction? 244 00:09:12,966 --> 00:09:16,233 This is the most exciting frontier in psychoneuroimmunology. 245 00:09:16,633 --> 00:09:18,766 And one study in particular is worth mentioning. 246 00:09:19,033 --> 00:09:21,900 This is a study of people with early-stage breast cancer. 247 00:09:22,166 --> 00:09:25,433 Published in Brain, Behavior and Immunity 248 00:09:25,766 --> 00:09:27,700 Researchers have just had surgery 249 00:09:27,733 --> 00:09:31,266 Breast cancer patients who had not yet received chemotherapy were divided into two groups 250 00:09:31,266 --> 00:09:34,433 One group participated in eight weeks of mindfulness stress reduction training 251 00:09:34,433 --> 00:09:35,600 The other group did not 252 00:09:35,833 --> 00:09:39,500 Then the immune markers of the two groups were tracked at four time points 253 00:09:39,833 --> 00:09:40,966 What's the result? 254 00:09:41,000 --> 00:09:42,666 At the outset of the study 255 00:09:42,666 --> 00:09:44,933 All breast cancer patients exhibited 256 00:09:44,933 --> 00:09:49,100 Decreased NK cell activity and elevated pro-inflammatory cytokines 257 00:09:49,666 --> 00:09:51,866 This fits perfectly with the mechanism we just talked about. 258 00:09:52,333 --> 00:09:55,133 A cancer diagnosis is a highly stressful event in itself 259 00:09:55,466 --> 00:09:57,200 The HPA axis is activated 260 00:09:57,200 --> 00:09:58,566 Immune function is suppressed 261 00:09:59,300 --> 00:10:01,100 But over time 262 00:10:01,100 --> 00:10:03,933 The two groups of people went in completely different directions 263 00:10:03,933 --> 00:10:05,633 The group that participated in mindfulness training 264 00:10:05,866 --> 00:10:08,066 NK cell activity is restored 265 00:10:08,100 --> 00:10:09,666 The pro-inflammatory factors went down. 266 00:10:09,666 --> 00:10:11,600 Cortisol levels are down. 267 00:10:11,633 --> 00:10:13,400 The group that did not participate in the training 268 00:10:13,600 --> 00:10:16,100 NK cell activity continues to decline 269 00:10:16,133 --> 00:10:17,900 Pro-inflammatory factors continue to rise 270 00:10:18,366 --> 00:10:19,166 Eight weeks 271 00:10:19,166 --> 00:10:20,566 The same diagnosis 272 00:10:20,566 --> 00:10:21,633 Same surgery. 273 00:10:21,900 --> 00:10:24,733 The only difference is that one interferes with the mental state 274 00:10:24,933 --> 00:10:25,833 One does not 275 00:10:26,100 --> 00:10:28,033 The immune system bifurcates. 276 00:10:28,533 --> 00:10:30,466 Does that remind you of something? 277 00:10:31,466 --> 00:10:31,966 Exactly. 278 00:10:32,200 --> 00:10:35,366 < Mind and Body Restart > The positive feedback closed loop I talked about in that issue 279 00:10:36,133 --> 00:10:36,833 I said at the time 280 00:10:37,100 --> 00:10:39,700 The mind-body system is a closed loop of positive feedback. 281 00:10:39,700 --> 00:10:41,433 Negative emotions drive inflammation 282 00:10:41,433 --> 00:10:43,500 Inflammation drives more negative emotions 283 00:10:43,533 --> 00:10:45,066 The system is becoming more and more biased 284 00:10:45,100 --> 00:10:48,666 Breaking the cycle requires system-wide intervention rather than a single point of repair 285 00:10:48,966 --> 00:10:52,800 Now you see this same structure at work in cancer immunity. 286 00:10:52,800 --> 00:10:54,633 Chronic stress suppresses immunity 287 00:10:54,633 --> 00:10:57,400 Immune decline leads to worsening physical condition 288 00:10:57,400 --> 00:11:00,033 Physical deterioration creates more stress 289 00:11:00,133 --> 00:11:02,166 More stress further suppresses immunity 290 00:11:02,200 --> 00:11:04,566 Another positive feedback death spiral 291 00:11:05,866 --> 00:11:07,766 And what do people in spontaneous remission do? 292 00:11:07,966 --> 00:11:09,633 They broke the spiral. 293 00:11:10,133 --> 00:11:12,066 Back to Turner's nine factors 294 00:11:12,100 --> 00:11:13,733 Release suppressed emotions 295 00:11:13,733 --> 00:11:15,566 Reduce chronic stress 296 00:11:15,600 --> 00:11:17,466 Increase positive emotions 297 00:11:17,500 --> 00:11:19,233 remodeling cortisol rhythm 298 00:11:19,233 --> 00:11:20,933 Embrace social support 299 00:11:20,966 --> 00:11:25,100 Research clearly confirms that social support boosts NK cell activity 300 00:11:25,100 --> 00:11:27,500 Have a strong reason to live 301 00:11:27,533 --> 00:11:30,033 Psychologically, it's called a sense of meaning. 302 00:11:30,033 --> 00:11:31,966 It is positively correlated with immune function 303 00:11:31,966 --> 00:11:33,966 Take control of your own health decisions 304 00:11:33,966 --> 00:11:35,800 Come out of helplessness 305 00:11:35,833 --> 00:11:39,966 And helplessness is one of the strongest immunosuppressive psychological states known. 306 00:11:40,833 --> 00:11:41,833 Did you see it? 307 00:11:41,866 --> 00:11:45,300 These nine factors are not a bunch of fragmented chicken soup for the soul 308 00:11:45,300 --> 00:11:48,766 When you look at them in the framework of psychoneuroimmunology 309 00:11:48,766 --> 00:11:51,233 They all point to the same thing. 310 00:11:51,233 --> 00:11:53,666 Through multiple psychological and behavioral channels 311 00:11:53,700 --> 00:11:56,133 Also reduce chronic stress responses 312 00:11:56,166 --> 00:11:58,700 Reverse that positive feedback death spiral 313 00:11:58,700 --> 00:12:00,733 Bring the immune system back online 314 00:12:01,666 --> 00:12:03,966 Now let me take the perspective one more level. 315 00:12:03,966 --> 00:12:06,333 Using one of the most important frameworks of our channel 316 00:12:06,366 --> 00:12:07,433 predictive coding 317 00:12:07,433 --> 00:12:08,533 Let's look at this question. 318 00:12:09,000 --> 00:12:12,033 Remember the core mechanics I talked about in the Predictive Coding issue? 319 00:12:12,066 --> 00:12:14,500 Your brain is not a passive receiver 320 00:12:14,500 --> 00:12:16,700 It's an active predictor. 321 00:12:16,700 --> 00:12:19,266 It becomes a prediction about the world. 322 00:12:19,300 --> 00:12:21,400 We then calibrate it with sensory data. 323 00:12:21,866 --> 00:12:24,400 Prior beliefs plus precision weights 324 00:12:24,400 --> 00:12:26,633 Determines what kind of reality you experience 325 00:12:27,200 --> 00:12:29,933 And we're now taking this framework and applying it to cancer patients. 326 00:12:31,166 --> 00:12:33,500 A person is diagnosed with advanced cancer 327 00:12:33,533 --> 00:12:34,966 The doctor told him 328 00:12:35,000 --> 00:12:36,300 Well, statistically speaking. 329 00:12:36,300 --> 00:12:38,000 You have about six months left. 330 00:12:38,000 --> 00:12:41,233 What does this mean in the context of predictive coding? 331 00:12:41,566 --> 00:12:44,633 It implants a very strong prior belief in the brain 332 00:12:44,633 --> 00:12:46,033 I'm going to die. 333 00:12:46,300 --> 00:12:49,633 And this prior belief has extremely high precision weights 334 00:12:49,633 --> 00:12:51,700 Because it comes from a medical authority 335 00:12:51,733 --> 00:12:53,233 From the video report 336 00:12:53,233 --> 00:12:54,533 From a pathological section 337 00:12:54,800 --> 00:12:57,033 From all the sources you trust 338 00:12:57,766 --> 00:13:01,200 What is the brain's response to this high-precision prior belief? 339 00:13:01,433 --> 00:13:04,066 Full Activation Threat Mode, HPA 340 00:13:04,100 --> 00:13:05,866 Axis continuous activation 341 00:13:05,866 --> 00:13:07,766 Cortisol spike 342 00:13:07,766 --> 00:13:10,700 The sympathetic nervous system enters a fight-or-flight state 343 00:13:11,166 --> 00:13:13,966 But this is not a fight-or-flight enemy. 344 00:13:14,000 --> 00:13:15,366 You have nowhere to run 345 00:13:15,366 --> 00:13:17,833 And that stress response becomes chronic. 346 00:13:17,866 --> 00:13:19,133 Become sustainable 347 00:13:19,133 --> 00:13:20,600 It's always on. 348 00:13:21,100 --> 00:13:23,033 Then the immune suppression kicks in. 349 00:13:23,500 --> 00:13:25,500 Positive feedback death spiral initiated 350 00:13:25,600 --> 00:13:27,200 But what about people in spontaneous remission? 351 00:13:27,200 --> 00:13:28,800 They at some point 352 00:13:28,800 --> 00:13:31,866 Experienced a major renewal of prior beliefs 353 00:13:32,033 --> 00:13:35,766 Some people just get desperate and open up. 354 00:13:35,766 --> 00:13:37,200 In Turner's words 355 00:13:37,233 --> 00:13:40,000 They found a strong reason to live. 356 00:13:40,000 --> 00:13:42,933 Some people are released after years of suppressed emotions 357 00:13:42,966 --> 00:13:46,600 I suddenly feel like my whole life has been reignited 358 00:13:46,600 --> 00:13:49,833 Some people make changes to their diet and lifestyle 359 00:13:49,866 --> 00:13:52,733 For the first time, I felt in control of my own destiny 360 00:13:52,733 --> 00:13:55,800 Some people are exposed to a certain spiritual practice 361 00:13:55,800 --> 00:13:58,666 Experienced a deep sense of calm and acceptance 362 00:13:58,900 --> 00:14:01,100 No matter what the specific trigger is 363 00:14:01,100 --> 00:14:03,200 From a predictive coding perspective 364 00:14:03,233 --> 00:14:04,933 They all do the same thing. 365 00:14:04,966 --> 00:14:09,300 Reduced the precision weight of the prior belief that I'm dying 366 00:14:09,300 --> 00:14:11,233 They don't necessarily deny the diagnosis 367 00:14:11,233 --> 00:14:15,033 But they no longer monopolize that cognitive bandwidth. 368 00:14:15,066 --> 00:14:18,266 Their brains start picking up other signals. 369 00:14:18,300 --> 00:14:20,333 I am actively working on something 370 00:14:20,366 --> 00:14:22,300 I have something worth living for 371 00:14:22,300 --> 00:14:24,733 I am no longer a passive victim 372 00:14:25,166 --> 00:14:28,533 These new signals recalibrate the brain's predictive models 373 00:14:28,566 --> 00:14:32,400 Threat mode is no longer the only mode of operation, HPA 374 00:14:32,400 --> 00:14:33,900 The shaft cools down. 375 00:14:33,933 --> 00:14:36,600 Cortisol returns to normal rhythm, NK 376 00:14:36,633 --> 00:14:38,733 The weapon of the cell has been returned 377 00:14:38,733 --> 00:14:41,066 Immune surveillance back online 378 00:14:41,300 --> 00:14:43,366 The positive feedback spiral is reversed. 379 00:14:43,533 --> 00:14:46,566 I need to draw a very clear red line here 380 00:14:46,900 --> 00:14:49,433 The mechanism I just described, the chain. 381 00:14:49,466 --> 00:14:53,566 From chronic stress to immune suppression to tumor progression 382 00:14:53,566 --> 00:14:56,800 This part is supported by a wealth of rigorous scientific evidence 383 00:14:56,800 --> 00:14:57,633 But 384 00:14:57,633 --> 00:15:02,066 From psychological transformation to reversal of immune suppression to spontaneous cancer remission 385 00:15:02,066 --> 00:15:04,700 And there's a huge jump in the middle. 386 00:15:04,700 --> 00:15:06,600 Current science can only say 387 00:15:06,600 --> 00:15:10,666 Psychological interventions can indeed improve immune markers in cancer patients 388 00:15:10,700 --> 00:15:13,566 But can it directly lead to tumor regression? 389 00:15:13,600 --> 00:15:16,833 How much can it cause the tumor to regress? 390 00:15:16,833 --> 00:15:19,933 These are questions that science has yet to answer. 391 00:15:20,433 --> 00:15:24,533 The true mechanism of spontaneous remission is almost certainly multifactorial 392 00:15:24,533 --> 00:15:27,700 Changes in the immune system may be just one part of it 393 00:15:27,700 --> 00:15:28,933 genetic factor 394 00:15:28,933 --> 00:15:30,533 The characteristics of the tumor itself 395 00:15:30,566 --> 00:15:32,400 Accidental changes in the microenvironment 396 00:15:32,400 --> 00:15:33,700 May participate 397 00:15:34,700 --> 00:15:37,400 So what I give you today is not just a good attitude, cancer. 398 00:15:37,433 --> 00:15:40,700 The irresponsible conclusion that the disease will go away on its own 399 00:15:40,733 --> 00:15:44,900 What I'm giving you is an inferential framework that stands up to scientific scrutiny. 400 00:15:44,900 --> 00:15:47,500 Chronic psychological stress does pass through traceability 401 00:15:47,500 --> 00:15:50,666 Neuroendocrine pathways suppress the immune system 402 00:15:50,700 --> 00:15:54,433 The immune system is one of the key defenses against cancer 403 00:15:54,433 --> 00:15:55,333 Therefore 404 00:15:55,366 --> 00:15:56,866 Reduce chronic stress 405 00:15:56,866 --> 00:15:58,566 Improve mental state 406 00:15:58,766 --> 00:16:01,266 And there are scientifically sound mechanisms for doing that. 407 00:16:01,300 --> 00:16:04,133 Support its positive impact on cancer progression 408 00:16:04,666 --> 00:16:06,100 This is not chicken soup for the soul. 409 00:16:06,100 --> 00:16:07,866 This is psychoneuroimmunology. 410 00:16:08,166 --> 00:16:11,400 So let me tell you about a question that I've been thinking about for a long time. 411 00:16:11,900 --> 00:16:15,000 Why do most cancer patients know that stress is bad? 412 00:16:15,000 --> 00:16:17,733 You can't really reduce your stress level. 413 00:16:17,833 --> 00:16:19,233 You think carefully 414 00:16:19,233 --> 00:16:21,566 The question itself holds the answer 415 00:16:22,166 --> 00:16:24,033 You've been diagnosed with terminal cancer. 416 00:16:24,033 --> 00:16:25,200 Someone told you 417 00:16:25,233 --> 00:16:25,933 relax 418 00:16:25,966 --> 00:16:27,233 Don't stress. 419 00:16:27,233 --> 00:16:28,466 Keep a good attitude 420 00:16:28,500 --> 00:16:31,000 Does your body react when it hears that? 421 00:16:31,033 --> 00:16:32,466 Almost none. 422 00:16:32,466 --> 00:16:35,000 Because within the framework of predictive coding 423 00:16:35,033 --> 00:16:37,466 Especially committed materialists 424 00:16:37,466 --> 00:16:42,366 Believing I'm dying is too precise a priori. 425 00:16:42,400 --> 00:16:43,966 It is reported by a confirmed diagnosis 426 00:16:43,966 --> 00:16:45,533 Medical authority 427 00:16:45,566 --> 00:16:47,400 Physical pain 428 00:16:47,400 --> 00:16:48,933 Fear in the eyes of family 429 00:16:49,200 --> 00:16:52,300 All of these high-precision signals are collectively anchored 430 00:16:52,333 --> 00:16:55,500 Don't think too much, you can't shake it at all 431 00:16:56,166 --> 00:16:58,933 That's the real gap between knowing and doing. 432 00:16:59,466 --> 00:17:00,866 It's not that the willpower is not enough 433 00:17:01,133 --> 00:17:02,800 Is the prior weight asymmetry 434 00:17:03,533 --> 00:17:04,900 A light word of advice 435 00:17:05,133 --> 00:17:08,733 Can't fight a belief anchored by the collusion of the whole of reality 436 00:17:09,500 --> 00:17:11,933 It's like I said in the Overview Effect. 437 00:17:11,966 --> 00:17:14,600 You watch pictures of the earth a hundred times on TV 438 00:17:14,600 --> 00:17:17,233 See the earth with your own eyes from space 439 00:17:17,266 --> 00:17:20,366 It's a completely different level of input to the brain. 440 00:17:20,366 --> 00:17:23,300 The former has negligible precision weights 441 00:17:23,333 --> 00:17:26,566 The latter is high enough to reconstruct your entire cognition 442 00:17:26,933 --> 00:17:28,000 Again. 443 00:17:28,000 --> 00:17:31,266 What a cancer patient needs is not to be told not to stress. 444 00:17:31,266 --> 00:17:33,700 It takes an experience powerful enough to shake it. 445 00:17:33,700 --> 00:17:37,566 The a priori belief that I was a helpless victim about to die 446 00:17:37,800 --> 00:17:39,766 What can this experience be? 447 00:17:39,866 --> 00:17:42,266 It can be deep mindfulness meditation. 448 00:17:42,266 --> 00:17:45,233 It's been shown to lower cortisol. 449 00:17:45,233 --> 00:17:47,333 Restore NK cell activity 450 00:17:47,366 --> 00:17:50,300 It can be the release of long-suppressed emotions 451 00:17:50,300 --> 00:17:52,833 When you finally allow yourself to cry 452 00:17:52,866 --> 00:17:53,866 Shout it out. 453 00:17:53,866 --> 00:17:55,233 When expressed 454 00:17:55,233 --> 00:18:00,066 The underlying chronic stress response to that emotion is also being released. 455 00:18:00,100 --> 00:18:03,366 It can be finding a strong reason to live. 456 00:18:03,400 --> 00:18:08,900 When your brain switches from waiting to die mode to living for something mode 457 00:18:08,900 --> 00:18:12,800 The parameters of the entire neuroendocrine system change 458 00:18:12,833 --> 00:18:15,133 It can be a supportive community. 459 00:18:15,166 --> 00:18:17,933 Social support is not chicken soup for the soul 460 00:18:17,933 --> 00:18:19,733 It can be measured. 461 00:18:19,833 --> 00:18:22,566 Biological variables that directly affect NK cell activity 462 00:18:23,200 --> 00:18:25,000 Turner's Nine Factors 463 00:18:25,000 --> 00:18:27,833 To recur in cases of spontaneous remission 464 00:18:27,866 --> 00:18:30,766 Perhaps precisely because they are one of the few 465 00:18:30,766 --> 00:18:33,733 An experience capable of generating high-precision weights 466 00:18:33,766 --> 00:18:37,066 To pry the transcendental belief that I was dying 467 00:18:37,100 --> 00:18:40,733 Pull someone out of a positive feedback death spiral 468 00:18:40,733 --> 00:18:42,466 Let me say that again. 469 00:18:42,466 --> 00:18:45,800 I'm not suggesting that psychological shifts are the only cause of spontaneous remission. 470 00:18:46,033 --> 00:18:49,933 And I'm not saying that you can cure cancer by doing these nine things. 471 00:18:49,966 --> 00:18:52,333 Cancer is an incredibly complex disease. 472 00:18:52,333 --> 00:18:55,333 Any oversimplified statement is irresponsible 473 00:18:55,633 --> 00:18:57,000 But here's the thing. 474 00:18:57,200 --> 00:19:00,533 Completely ignoring the role of psychological factors in the progression of cancer 475 00:19:00,866 --> 00:19:02,366 Also unscientific 476 00:19:02,600 --> 00:19:05,033 Psycho-neuroimmunological studies over the past 40 years 477 00:19:05,033 --> 00:19:07,433 Enough evidence has been accumulated to suggest that 478 00:19:07,433 --> 00:19:10,533 Mental state is not an irrelevant soft variable 479 00:19:10,566 --> 00:19:12,366 It's down the HPA axis. 480 00:19:12,366 --> 00:19:13,966 Sympathetic nervous system 481 00:19:14,000 --> 00:19:15,633 inflammatory cytokines, NK 482 00:19:15,666 --> 00:19:18,200 Cell activity, etc. can be tracked 483 00:19:18,200 --> 00:19:19,633 Measurable path 484 00:19:19,633 --> 00:19:22,400 It's actually affecting your immune system. 485 00:19:23,166 --> 00:19:24,200 optimal strategy 486 00:19:24,400 --> 00:19:27,933 Forever mainstream medical treatment plus comprehensive mind-body intervention 487 00:19:28,166 --> 00:19:28,966 It's not an option. 488 00:19:29,966 --> 00:19:30,466 OK 489 00:19:30,600 --> 00:19:31,400 So much for that. 490 00:19:31,600 --> 00:19:33,766 Let me distill what I'm about to say today. 491 00:19:33,966 --> 00:19:37,266 The core message of this issue is actually only one sentence 492 00:19:37,266 --> 00:19:40,466 Between your mental state and your immune system 493 00:19:40,600 --> 00:19:42,033 There is no wall. 494 00:19:42,266 --> 00:19:43,533 I'll say it again. 495 00:19:43,766 --> 00:19:44,666 That wall doesn't exist. 496 00:19:45,566 --> 00:19:46,733 They are highly correlated. 497 00:19:47,466 --> 00:19:48,633 For a long time 498 00:19:48,666 --> 00:19:53,400 Mainstream medicine treats the body and the mind as two relatively independent systems 499 00:19:53,933 --> 00:19:55,066 You have cancer? 500 00:19:55,100 --> 00:19:56,300 Go to oncology 501 00:19:56,300 --> 00:19:57,600 You have emotional problems 502 00:19:57,633 --> 00:19:58,966 Go to Psychology 503 00:19:58,966 --> 00:20:01,566 There is basically no communication between the two departments 504 00:20:02,933 --> 00:20:05,100 But what psychoneuroimmunology tells us is that 505 00:20:05,433 --> 00:20:08,400 These two systems are not neighbors who live on different floors 506 00:20:08,766 --> 00:20:10,400 They live in the same house 507 00:20:10,700 --> 00:20:12,400 Sharing the same pipeline 508 00:20:12,733 --> 00:20:14,600 Cortisol is the water that flows in pipes. 509 00:20:14,933 --> 00:20:17,233 Your psychological stress turns on the faucet 510 00:20:17,500 --> 00:20:19,800 High cortisol initializes your immune cells, NK 511 00:20:20,166 --> 00:20:21,633 Cells are flooded 512 00:20:21,633 --> 00:20:23,266 Immune surveillance failure 513 00:20:23,300 --> 00:20:25,533 Cancer cells have an opportunity 514 00:20:26,033 --> 00:20:26,733 reverse 515 00:20:27,000 --> 00:20:29,400 When you find a way to turn off that faucet 516 00:20:29,666 --> 00:20:31,600 Cortisol returns to normal levels, NK 517 00:20:31,800 --> 00:20:34,133 The cell takes up arms again. 518 00:20:34,266 --> 00:20:36,366 Immune surveillance back online 519 00:20:37,733 --> 00:20:39,600 It's not that the mind can heal. 520 00:20:40,033 --> 00:20:40,900 This is saying 521 00:20:41,100 --> 00:20:44,633 Your mental state is channeled through very specific biochemical pathways 522 00:20:44,833 --> 00:20:47,833 Directly involved in the operation of your body's defense system 523 00:20:48,166 --> 00:20:49,200 Ignore this 524 00:20:49,233 --> 00:20:51,466 You're missing a powerful tool. 525 00:20:51,466 --> 00:20:54,033 Maybe even the most powerful nuclear weapon 526 00:20:54,033 --> 00:20:56,666 Because this process of immunity repairing itself 527 00:20:56,700 --> 00:20:58,866 Compared to the doctor's treatment 528 00:20:58,900 --> 00:21:00,700 There are no side effects at all. 529 00:21:00,733 --> 00:21:03,266 It can even fix other basic diseases by the way 530 00:21:03,633 --> 00:21:06,866 But it also left a question that I'm still wondering 531 00:21:07,166 --> 00:21:11,900 If psychological states do influence the course of cancer through the immune system 532 00:21:11,933 --> 00:21:14,666 So where is the ceiling of this influence? 533 00:21:14,833 --> 00:21:16,666 Spontaneous remission does exist 534 00:21:16,700 --> 00:21:19,633 3,500 medical literature cases are not made up 535 00:21:19,633 --> 00:21:21,733 But it's incredibly rare. 536 00:21:21,766 --> 00:21:24,633 The vast majority of cancer patients, no matter how good they are 537 00:21:24,633 --> 00:21:27,500 Psychological transformation alone cannot cure cancer. 538 00:21:27,800 --> 00:21:30,100 So what is spontaneous remission? 539 00:21:30,100 --> 00:21:32,566 It is the immune system under very specific conditions 540 00:21:32,600 --> 00:21:35,933 A small probability quantum tunneling event 541 00:21:35,966 --> 00:21:39,700 It's a perfect storm where multiple factors happen to align at the same time 542 00:21:39,700 --> 00:21:42,800 Or is our understanding of the immune system still far from complete? 543 00:21:42,800 --> 00:21:46,933 The future may find its potential far beyond our imagination 544 00:21:47,100 --> 00:21:48,066 This question 545 00:21:48,066 --> 00:21:50,066 Science cannot answer for the time being 546 00:21:50,666 --> 00:21:53,133 But ION and Kelly Turner, what they did 547 00:21:53,133 --> 00:21:56,500 At least it points us in a direction worth taking seriously 548 00:21:56,800 --> 00:21:58,733 Don't just focus on the tumor itself 549 00:21:58,733 --> 00:22:00,833 Also look at the person carrying the tumor 550 00:22:00,866 --> 00:22:02,166 His mental state 551 00:22:02,200 --> 00:22:04,466 His beliefs and his way of coping 552 00:22:04,466 --> 00:22:05,833 His immune system 553 00:22:05,833 --> 00:22:07,266 His social support 554 00:22:07,300 --> 00:22:10,233 Because these things are not icing on the cake. 555 00:22:10,233 --> 00:22:13,100 They may be a grossly underestimated part of the treatment package 556 00:22:13,566 --> 00:22:15,500 Maybe one day we will find out 557 00:22:15,500 --> 00:22:16,933 The most powerful medicine 558 00:22:16,933 --> 00:22:18,700 It's always in you. 559 00:22:18,800 --> 00:22:22,166 We just don't know exactly how to pull it out yet. 560 00:22:22,466 --> 00:22:23,800 For the content of this issue 561 00:22:23,833 --> 00:22:25,233 What do you think? 562 00:22:25,233 --> 00:22:28,466 Have you or someone close to you ever experienced a psychological condition? 563 00:22:28,466 --> 00:22:32,533 Great changes in state bring about an experience of improved physical health 564 00:22:32,566 --> 00:22:35,300 What topic would you most like me to talk about in the next issue? 565 00:22:35,333 --> 00:22:36,833 Welcome to leave a message in the comment area. 566 00:22:37,166 --> 00:22:38,200 I am Wang Lijie 567 00:22:38,333 --> 00:22:39,066 See you next time.